Failed IVF CYCLE…. WHAT NEXT??
Hope is still there!!!
It is known, the success rate of IVF per cycle is 50-60% all over the globe.
Recurrent implantation failure is defined as “more than 3 embryo transfers with high quality embryos or the transfer of, more than equal to 10 embryos in multiple transfers; exact numbers to be determined by each centre.”
Treatment of Recurrent IVF failure
1) Pre-ART Therapy:
Patient will be evaluated through different blood test for her hemoglobin , calcium , vit D , etc levels and supplements like Folic Acid, Zinc, Selenium, Co-Enzyme Q , etc are given to improve the wellness as well as the quality of eggs and sperm of the couple.
Poor responders are advised to take DHEA, L Arginine,Wheatgrass as it improves the ovarian response and improve the egg and sperm quality.
PCOS patients are given insulin sensitizing agents like metformin and myo- inisitol. Weight control and a proper balanced diet is necessary in obese PCOS patients.
2) Individualized protocol:
The protocol is decided after carefully studying the history and investigations of each couple along with hormonal profile.
3) Sperm selection using ICSI:
In order to improve the pregnancy outcome, our embryologist take special care to select the best sperms while doing ICSI.
This is done in case of all patients with implantation failure. Hysteroscopy helps the clinician get a clearer picture of uterine abnormalities which are sometimes missed on ultrasound. Endometrial scratching is also done at the same setting, as it helps in improving the endometrial receptivity thereby increasing the chance of getting pregnant.
5) Doppler flow:
Drugs like sildenafil, G-CSF, is given to the patient to improve the blood supply to the endometrial lining and ultrasound-doppler is done before transfer to see the same. PRP (Platelet rich plasma) is also used for the growth of endometrium.
6) Uterine relaxants:
These are given one hour prior to transfer and approximately 6 hours post transfer as these are known to improve implantation of embryo to the endometrial lining.
7) Laser Hatching:
This is performed on the day of embryo transfer in order to improve the chances of implantation. It is usually suitable for embryos with thick shell, frozen embryos or in case of embryos of patients with advanced maternal age.
8) Pre-implantation genetic Diagnosis (PGD)/PGS:
This helps in detecting abnormal embryos, further helping in improving the pregnancy rates.
9) Day of transfer:
In some cases sequential transfers are advised when embryos are available or day 5/day 3 embryo transfers are done accordingly. The sequential transfer of Day 3 embryos followed by Day 5 embryos in the same cycle is referred to as Sequential embryo transfer. According to various studies conducted, this method of transfer has been reported to increase the implantation window, further improving the pregnancy outcome in patients with repeated IVF-ET failure. All the embryo transfers are done by Dr. Jyoti Bali who has a vast experience of 15 years in doing embryo transfers.
What do we expect from you?
Patients are advised to stay positive and maintain a healthy lifestyle. One of the most important things during this process is strong will-power and an optimistic approach.
“Key to success lies in individualized approach!!”