Intrauterine Insemination (IUI) is a simple fertility procedure in which processed (concentrated and washed) sperms are placed inside a woman’s uterus during the period of ovulation, in order to increase her chances of becoming pregnant. The principle behind IUI is that a large number of sperms reach the egg in the fallopian tubes, increasing the likelihood of fertilization. Pregnancy can then follow naturally inside the body.

Who Needs IUI?

Low volume of semen
Low sperm count
Ejaculatory failure
Retrograde Ejaculation
Reduced sperm motility
Increase no. of abnormal sperm
Ovulatory dysfunction
Minimal to mild endometriosis
Female anti sperm antibodies (cervical mucus)
Thick cervical mucus
Unexplained infertility

Steps of IUI

  • IUI can be done in a natural cycle or a stimulated cycle (where medications are used for ovulation).
  • Ovulation Induction starts from day 2 of the cycle. Where only tablets (Ovulation induction drugs) for 5 days, followed by hormone injection for 4-5 days which may or may not be required.
  • Follicular monitoring- For natural cycles the follicular monitoring starts from day 9 or day 10 of the cycle whereas in stimulated cycles the monitoring begins from day 2 of the cycle. Scans are done to monitor follicle growth. Total of 3-4 ultrasounds are required. Once the size of the follicle reaches 18-22mm a trigger injection is given.
  • Trigger Injection- Trigger Injection causes the follicle or follicles to rupture and release the egg.
  • Scan- it is done for the confirmation of follicle rupture after 36-38 hours.
  • Sperm Collection and Insemination- A washed and healthy semen sample by the andrologist in the IUI lab is used to inseminate in the uterus of the women.
  • Pregnancy Test- Beta HCG test (which is a confirmatory test for pregnancy) is performed after 14 days to confirm the pregnancy.

Cases where IUI cannot be done

One or both tubes blocked (Fallopian tube blockage)

  • Genital tract infection
  • Unexplained genital tract bleeding
  • Tubal pathology
  • Genetic abnormalities
  • Pelvic mass
  • Pelvic surgeries
  • Severe illness in one or both partners
  • Recent Chemotherapy and Radiotherapy

Success rate of IUI

IUI success rate is up to 20% per cycle. We advise at least minimum of 3-4 cycles to be taken before other options like IVF is considered

The results of IUI depends upon several factors:-

  • Age of both partners
  • Duration of infertility
  • Causes of infertility
  • Sperm parameters
  • Treatment cycle rank (first, second or third cycle)

What do we expect from you?

A healthy life style which will include work life balance and nutritious diet, and in place an exercise schedule. Harmony between mind, body and soul to alleviate stress which will go a long way in coping up with the treatment and increasing the success rates. For men, we advise to refrain from ejaculation 2-3 days prior to the procedure. It helps improving the sperm quality on the day of IUI thereby, increasing the chances of conception.

Frequently asked questions

Q1. What is IUI?

Ans- Intrauterine Insemination (IUI) is a basic fertility technique in which processed (concentrated and washed) sperms are implanted into a woman’s uterus during ovulation to boost her chances of becoming pregnant.

Q2. Is IUI different from IVF treatment?

Ans- Fertilization (meeting of egg and sperm) occurs in the body during IUI (fallopian tubes). IVF, on the other hand, is carried out in a laboratory

Q3. What is the success rate of IUI?

Ans- The success rate of IUI is approximately 20%

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